Case 2

Patient #2, a 2 year old male with a history of DiGeorge Syndrome and complex congenital heart disease. Following cardiac surgery, he developed a recalcitrant multidrug resistant Pseudomonas aeruginosa bacteremia. Bacteriophage therapy was initiated intravenously, but then held due to progressive heart failure. Despite premature cessation of therapy, blood cultures obtained 4 and 5 days subsequently were sterile. Therapy was resumed 11 days after cessation, and blood cultures that had become positive reverted back to sterile. Unfortunately, the patient decompensated, presumably due to progression of undrained fluid collections, antecedent influenza infection, and end-stage cardiac failure. This case was published in the Journal of Pediatric Infectious Diseases Society as “Refractory Pseudomonas Bacteremia in a 2-Year-Old Sterilized by Bacteriophage Therapy” (Duplessis 2017).