Case 12

Patient #12, a 36-year-old male who, due to a spinal injury, is an incomplete quadriplegic and has an ileal conduit. For over a year, he suffered from recurrent urinary tract infections (RUTI) and bacteremia caused by an extended spectrum beta-lactamase (ESBL) producing strain of Escherichia coli. His phage therapy began February consisted of two different phage products with titers between 1.0 x 10^8 and 7.0 x 10^ 8 PFU/mL. The treating physician administered the phage products twice daily intravenously during weekdays and directly into the patient’s ileal conduit once per week. The patient began receiving antibiotics during their phage therapy to address sacral ulcer. At the doctor’s request, therapy was stopped after 13 doses as the patient was now culture negative. The patient remained culture negative for two months but was readmitted into the hospital with reoccurring symptoms.