Publications

All Publications

Title Journal Description
Title Luminescent Phage-Based Detection of Klebsiella pneumoniae: From Engineering to Diagnostics Jorunal Pharmaceuticals Description

Using a conventional method and a new cloning approach to develop luminescent phages, we engineered two phages that specifically detect a disease-associated microbial strain. We performed phage sensitivity assays in liquid culture and in fecal matrices and tested the stability of spiked fecal samples stored under different conditions. Different reporter gene structures and genome insertion sites were required to successfully develop the two nluc-reporter phages.

Title Novel Analysis of Fusobacterium Nucleatum Species in Human Colorectal Cancer and Engineering of Therapeutic Bacteriophage Jorunal ESMO-IO Description

Recent studies demonstrate that bacterial species are present within the tumor microenvironment. Fusobacterium nucleatum is significantly enriched in human colorectal carcinomas, and its presence correlates with advanced tumor stage and poor prognosis.

Title Broad Host Range Bacteriophage For Reduction Of Klebsiella Pneumoniae As Potential Therapy In Primary Sclerosing Cholangitis (Psc) Jorunal AASLD Conference 2020 Description

Primary sclerosing cholangitis (PSC) is a rare immunerelated disease. Strains of Klebsiella pneumoniae (KP) have been suggested as a potential therapeutic target in PSC, as KP isolated from PSC patients’ stool were shown to cause Th17 immune stimulation and an increase in gut permeability in germ-free WT or DDC-treated mice

Title Activity of Bacteriophage Against Multidrug Resistant Klebsiella Pneumoniae Jorunal IDWeek Conference 2020 Description

The prevalence of extended-spectrum beta-lactamase (ESBL) producing and carbapenem resistant (CR) Klebsiella pneumoniae (KP) has significantly risen worldwide. Infections due to these bacteria are of increasing clinical concern and associated with high mortality across different infection types

Title Development of natural bacteriophages for skin care Jorunal AAD Conference, March 2020 Description

The extensive use of topical and oral antibiotics to address this condition has led to widespread antibiotic resistance in C. acnes. Furthermore, the common growth formation of these bacteria in polysaccharide-rich biofilm matrices also protects them from antibiotic activity

Title Novel phages targeting intratumor associated fusobacterium nucleatum Jorunal AACR Conference, Orlando FL, February 2020 Description

Recent studies demonstrate that bacterial species are present within the tumor microenvironment