Publications

All Publications

Title Journal Description
Title A Phase 1, Randomized, Single-Blind, Placebo-Controlled Pharmacokinetic Study Evaluating Oral BX002-A Bacteriophage Therapy Jorunal AASLD Conference 2021 Description

Orally administered BX002 in first-in-human study was shown to be safe and well-tolerated in healthy adults. PK analysis showed high levels of viable phage in stool at sufficient levels to interact with target bacteria after passage through gastrointestinal tract.

Title Engineering phages for eukaryotic payload expression in cancer associated Fusobacterium nucleatum Jorunal EMBL symposia 2021 Description

Phage have high intrinsic safety and specificity and offer a promising treatment strategy to target Fusobacterium nucleatum associated with colorectal cancer. Here we demonstrate the ability to express a eukaryotic protein in an unconventional bacterial host using a sequence designed by computational tools.

Title Development of Bacteriophage Cocktail Targeting Staphylococcus aureus to Treat Atopic Dermatitis Jorunal Revolutionizing Atopic Dermatitis (RAD) 2021 Virtual Conference Description

S. aureus contributes to atopic dermatitis pathogenesis through the release of virulence factors that affect the keratinocytes and immune cells. A broad host range cocktail of natural phages targeting S. aureus was effective in reducing bacterial burden in-vitro and holds the potential to offer a novel therapeutic approach for atopic dermatitis.

Title Phage Therapy for Chronic Pseudomonas aeruginosa Infections in Cystic Fibrosis Patients Jorunal EFCF Conference 2020 Description

Chronic respiratory infections with Pseudomonas aeruginosa are a major cause of morbidity and mortality in Cystic Fibrosis patients. We provide in vitro results of a novel phage cocktail targeting Pseudomonas aeruginosa.

Title Luminescent Phage-Based Detection of Klebsiella pneumoniae: From Engineering to Diagnostics Jorunal Pharmaceuticals Description

Using a conventional method and a new cloning approach to develop luminescent phages, we engineered two phages that specifically detect a disease-associated microbial strain. We performed phage sensitivity assays in liquid culture and in fecal matrices and tested the stability of spiked fecal samples stored under different conditions. Different reporter gene structures and genome insertion sites were required to successfully develop the two nluc-reporter phages.

Title Novel Analysis of Fusobacterium Nucleatum Species in Human Colorectal Cancer and Engineering of Therapeutic Bacteriophage Jorunal ESMO-IO Description

Recent studies demonstrate that bacterial species are present within the tumor microenvironment. Fusobacterium nucleatum is significantly enriched in human colorectal carcinomas, and its presence correlates with advanced tumor stage and poor prognosis.